The research leading to these results has received funding from the Norway Grants 2014-2021 via the National Centre for Research and Development
Project Highlights
In the proposed study a novel 3-layered and composite biopolymer scaffold of customizable porous structure and preset biological activity will be prepared. The scaffold will be composed of three functional layers: 1st one constituting for the mechanical stability and durability in biological conditions, while mimicking the extracellular matrix (ECM), 2nd the upper serving for supporting the favorable environment, humidity, elasticity and enhancing the cell growth and proliferation - will be made of selected biopolymers enriched with the selected active compounds, and 3rd the functional coating with bactericidal and bacteriostatic properties and reducing the hydrophilicity. It is expected that the prepared structure will be universal for different applications and easily adjusted for the final application.
The results of the proposed project can used in the guided bone and tissue regeneration treatments (GBTR). The last part of the project anticipates the elaboration of the variant of scaffold directed to the use in skin cell engineering (prototype).
WP1 - 1st layer
Obtaining a collagen based freeze-dried foam-like structure with increased mechanical resistance and relative stability under physiological conditions in vitro.
WP 2 - 2nd layer
Obtaining a freeze-dried foam-like structure with a programmed porous structure, enriched with active compunds providing favourable environment to cells and the source of nutrients, as well as activity of the bioactive compounds.
WP 3 – prototype and biological testing
Obtaining a prototype of a 3-layered composite construct aimed at application in skin tissue engineering enriched with active compounds.